The HLA-DRB1*01:03 genetic variant is associated with severe ulcerative colitis, significantly raising the risk of major surgeries and hospitalizations.
Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis.
There is a strong connection between inflammatory bowel disease (IBD) and spondyloarthritis - a condition that causes pain and stiffness in the joints.
The study identifies links between gut microbiota, genetic variants in IBD, and mental health disorders, offering insights into potential biomarkers for CMDs.
